Absolutely. Though some high-stall torque converters may affect final results, tuning can be done on a dreamscience dyno just like on the road. Interestingly, hub-type dynos can only test vehicles with manual transmissions. Since a hub-type dynamometer has no inertia, automatic transmissions and torque converters give them fits. Dynapack claims to have a solution forthcoming - however, as their mechanical design is the drawback, their solution will likely be complicated and costly.